开展同步辐射线站技术研究，目前是合肥光源极紫外相干线站负责人，同时负责合肥先进光源（HALF）中能显微谱学成像线站的光学设计。在Opt. Express, Appl. Phys. Lett., Med. Phys., Phys. Med. Biol. 等重要期刊上发表论文20余篇。

研究方向：

干涉光刻、X射线纳米显微成像方法，X射线光栅相衬成像方法及信息恢复，CT重构算法，深度学习。

代表论文：

1. Z. Wu^#, G. B. Zan#, Q. S. Lin, Y. Guan, L. J. Tian, K. Gao, Z. L. Wang, P. P. Zhu, W. B. Yun, G. Liu, Y. L. Lu, and Y. C. Tian, Flexible X-ray Talbot-Lau interferometer and its theory, Optics Express 33(3), 6278-6289 (2025).

2. C. Zhang, Y. Guan, X. Y. Tao, L. J. Tian, L. Chen, Y. Xiong, G. Liu, Z. Wu* and Y. C. Tian*, On-line correlative imaging of cryo-PALM and soft X-ray tomography for identification of subcellular structures， Optics Express 32 (16), 27508-27518 (2024).

3. Q. S. Lin, Z. Wu*, M. Huang, Z. Dang, L. J. Tian, Y. Guan, G. Liu, Y. L. Lu, and Y. C. Tian*, Detection of early pulmonary emphysema by multi-contrast x-ray Talbot-Lau interferometer, Med Phys. 2024, 1–10 (2024).

4. X. Y. Tao, Z. Dang, Y. T. Zheng, C. Zhang, Y. Guan, Z. Wu*, G. Liu*，and Y. C Tian, Limited-angle artifacts removal and jitter correction in soft xray tomography via physical model-driven deep learning, Appl. Phys. Lett. 123, 191101 (2023).

5. Q. S. Lin, Z. Wu*, G. B. Zan, M. Huang, Z. Dang, L. J. Tian, Y. Guan, G. Liu, Y. Li. Lu, and Y. C. Tian*, High energy x-ray Talbot-Lau interferometer employing a microarray anode-structured target source to extend the field of view, Phys. Med. Biol. 68, 21NT01 (2023).

6. Z. Wu, K. Gao, Z. L. Wang, S. X. Wang, P. P. Zhu, Y. Q. Ren, and Y. C. Tian*. Generalized reverse projection method for grating-based phase tomography. J. Synchrotron Rad. 28: 854-863 (2021).

7. Z. Wu^#, W. B. Wei^#, K. Gao*, G. Liu, G. F. Liu, H. X. Sun, J. Jiang, Q. P. Wang, Y. L. Lu*, and Y. C. Tian*, Prototype system of noninterferometric phase-contrast computed tomography utilizing medical imaging components. J. Appl. Phys. 129, 074901 (2021).

8. Z. Wu^#, K. Gao^#, Z. L. Wang, Q. G. Shao, R. F. Hu, C. X. Wei, G. B. Zan, F. Wali, R. H. Luo, P. P. Zhu, and Y. C. Tian*, Linear information retrieval method in X-ray grating-based phase contrast imaging and its interchangeability with tomographic reconstruction, J. Appl. Phys. 121(21), 213102 (2017).

9. Z. Wu, K. Gao, J. Chen, D. J. Wang, S. H. Wang, H. Chen, Y. Bao, Q. G. Shao, Z. L. Wang*, K. Zhang, P. P. Zhu, and Z. Y. Wu*, High sensitivity phase retrieval method in grating-based x-ray phase contrast imaging, Med. Phys. 42(2), 741-749 (2015).

10. Z. Wu, K. Gao, Z. L. Wang*, X. Ge, J. Chen, D. J. Wang, Z. Y. Pan, K. Zhang, P. P. Zhu, and Z. Y. Wu*, A new method to retrieve phase information for equiangular fan beam differential phase contrast computed tomography, Med. Phys. 40(3), 031911, (2013).